| Southampton FC vs. Wrexham AFC | 8-9-2025
Saturday
12:30 PM | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Stoke City FC | 8-23-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Middlesbrough FC | 9-27-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Swansea City AFC | 10-18-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Preston North End | 11-1-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Sheffield Wednesday FC | 11-8-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Leicester City FC | 11-25-2025
Tuesday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Birmingham City FC | 12-6-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. West Bromwich Albion FC | 12-9-2025
Tuesday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Coventry City FC | 12-20-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Millwall FC | 1-1-2026
Thursday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Hull City AFC | 1-17-2026
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Watford FC | 2-7-2026
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Charlton Athletic FC | 2-21-2026
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Queens Park Rangers FC | 2-24-2026
Tuesday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Norwich City FC | 3-7-2026
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Oxford United | 3-21-2026
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Ipswich Town FC | 4-3-2026
Friday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Derby County FC | 4-11-2026
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Bristol City FC | 4-21-2026
Tuesday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Blackburn Rovers | 4-25-2026
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
