| FSV Mainz 05 vs. FC Koln | 8-23-2025
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| VfL Wolfsburg vs. FSV Mainz 05 | 8-30-2025
Saturday
TBD | Volkswagen Arena in Wolfsburg, Germany | View Tickets |
| FSV Mainz 05 vs. RB Leipzig | 9-13-2025
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| FC Augsburg vs. FSV Mainz 05 | 9-20-2025
Saturday
TBD | WWK Arena in Augsburg, Germany | View Tickets |
| FSV Mainz 05 vs. Borussia Dortmund | 9-27-2025
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| Hamburger SV vs. FSV Mainz 05 | 10-4-2025
Saturday
TBD | Volksparkstadion in Hamburg, Germany | View Tickets |
| FSV Mainz 05 vs. Bayer 04 Leverkusen | 10-18-2025
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| VfB Stuttgart vs. FSV Mainz 05 | 10-25-2025
Saturday
TBD | MHPArena in Stuttgart, Germany | View Tickets |
| FSV Mainz 05 vs. SV Werder Bremen | 11-1-2025
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| Eintracht Frankfurt vs. FSV Mainz 05 | 11-8-2025
Saturday
TBD | Deutsche Bank Park in Frankfurt am Main, Germany | View Tickets |
| FSV Mainz 05 vs. TSG 1899 Hoffenheim | 11-22-2025
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| SC Freiburg vs. FSV Mainz 05 | 11-29-2025
Saturday
TBD | Europa-Park Stadion in Freiburg im Breisgau, Germany | View Tickets |
| FSV Mainz 05 vs. Borussia Monchengladbach | 12-6-2025
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| FC Bayern Munich vs. FSV Mainz 05 | 12-13-2025
Saturday
TBD | Allianz Arena in München, Germany | View Tickets |
| FSV Mainz 05 vs. FC St. Pauli | 12-20-2025
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| FC Union Berlin vs. FSV Mainz 05 | 1-10-2026
Saturday
TBD | Stadion An Der Alten Forsterei in Berlin, Germany | View Tickets |
| FSV Mainz 05 vs. FC Heidenheim | 1-14-2026
Wednesday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| FSV Mainz 05 vs. VfL Wolfsburg | 1-24-2026
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| RB Leipzig vs. FSV Mainz 05 | 1-31-2026
Saturday
TBD | Red Bull Arena in Leipzig, Germany | View Tickets |
| FSV Mainz 05 vs. FC Augsburg | 2-7-2026
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| Borussia Dortmund vs. FSV Mainz 05 | 2-14-2026
Saturday
TBD | Westfalenstadion in Dortmund, Germany | View Tickets |
| FSV Mainz 05 vs. Hamburger SV | 2-21-2026
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| Bayer 04 Leverkusen vs. FSV Mainz 05 | 2-28-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| FSV Mainz 05 vs. VfB Stuttgart | 3-7-2026
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| SV Werder Bremen vs. FSV Mainz 05 | 3-14-2026
Saturday
TBD | Weserstadion in Bremen, Germany | View Tickets |
| FSV Mainz 05 vs. Eintracht Frankfurt | 3-21-2026
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| TSG 1899 Hoffenheim vs. FSV Mainz 05 | 4-4-2026
Saturday
TBD | PreZero Arena in Sinsheim-Hoffenheim, Germany | View Tickets |
| FSV Mainz 05 vs. SC Freiburg | 4-11-2026
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| Borussia Monchengladbach vs. FSV Mainz 05 | 4-18-2026
Saturday
TBD | Borussia Park in Mönchengladbach, Germany | View Tickets |
| FSV Mainz 05 vs. FC Bayern Munich | 4-25-2026
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| FSV Mainz 05 vs. FC Union Berlin | 5-9-2026
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
