| SV Werder Bremen vs. Bayer 04 Leverkusen | 8-30-2025
Saturday
TBD | Weserstadion in Bremen, Germany | View Tickets |
| Bayer 04 Leverkusen vs. Eintracht Frankfurt | 9-13-2025
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Bayer 04 Leverkusen vs. Borussia Monchengladbach | 9-20-2025
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Bayer 04 Leverkusen vs. FC Union Berlin | 10-4-2025
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| FSV Mainz 05 vs. Bayer 04 Leverkusen | 10-18-2025
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| Bayer 04 Leverkusen vs. SC Freiburg | 10-25-2025
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| FC Bayern Munich vs. Bayer 04 Leverkusen | 11-1-2025
Saturday
TBD | Allianz Arena in München, Germany | View Tickets |
| Bayer 04 Leverkusen vs. FC Heidenheim | 11-8-2025
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| VfL Wolfsburg vs. Bayer 04 Leverkusen | 11-22-2025
Saturday
TBD | Volkswagen Arena in Wolfsburg, Germany | View Tickets |
| Bayer 04 Leverkusen vs. Borussia Dortmund | 11-29-2025
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| FC Augsburg vs. Bayer 04 Leverkusen | 12-6-2025
Saturday
TBD | WWK Arena in Augsburg, Germany | View Tickets |
| RB Leipzig vs. Bayer 04 Leverkusen | 12-20-2025
Saturday
TBD | Red Bull Arena in Leipzig, Germany | View Tickets |
| Bayer 04 Leverkusen vs. VfB Stuttgart | 1-10-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Hamburger SV vs. Bayer 04 Leverkusen | 1-14-2026
Wednesday
TBD | Volksparkstadion in Hamburg, Germany | View Tickets |
| TSG 1899 Hoffenheim vs. Bayer 04 Leverkusen | 1-17-2026
Saturday
TBD | PreZero Arena in Sinsheim-Hoffenheim, Germany | View Tickets |
| Bayer 04 Leverkusen vs. SV Werder Bremen | 1-24-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Borussia Monchengladbach vs. Bayer 04 Leverkusen | 2-7-2026
Saturday
TBD | Borussia Park in Mönchengladbach, Germany | View Tickets |
| Bayer 04 Leverkusen vs. FC St. Pauli | 2-14-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Bayer 04 Leverkusen vs. FSV Mainz 05 | 2-28-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| SC Freiburg vs. Bayer 04 Leverkusen | 3-7-2026
Saturday
TBD | Europa-Park Stadion in Freiburg im Breisgau, Germany | View Tickets |
| Bayer 04 Leverkusen vs. FC Bayern Munich | 3-14-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Bayer 04 Leverkusen vs. VfL Wolfsburg | 4-4-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Borussia Dortmund vs. Bayer 04 Leverkusen | 4-11-2026
Saturday
TBD | Westfalenstadion in Dortmund, Germany | View Tickets |
| Bayer 04 Leverkusen vs. FC Augsburg | 4-18-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
